Back to Search
Start Over
Cardiovascular mortality risk in patients with ovarian cancer: a population-based study.
- Source :
-
Journal of ovarian research [J Ovarian Res] 2024 Apr 25; Vol. 17 (1), pp. 88. Date of Electronic Publication: 2024 Apr 25. - Publication Year :
- 2024
-
Abstract
- Objectives: Ovarian cancer (OC) can occur at different ages and is affected by a variety of factors. In order to evaluate the risk of cardiovascular mortality in patients with ovarian cancer, we included influencing factors including age, histological type, surgical method, chemotherapy, whether distant metastasis, race and developed a nomogram to evaluate the ability to predict occurrence. At present, we have not found any correlation studies on cardiovascular death events in patients with ovarian cancer. This study was designed to provide targeted measures for effective prevention of cardiovascular death in patients with ovarian cancer.<br />Methods: Kaplan-Meier analysis and multivariable Cox proportional model were performed to evaluate the effectiveness of cardiovascular diseases on overall survival (OS) and ovarian cancer-specific survival (OCSS). We compared multiple groups including clinical, demographic, therapeutic characteristics and histological types. Cox risk regression analysis, Kaplan-Meier survival curves, and propensity score matching were employed for analyzing the data.<br />Results: A total of 88,653 ovarian cancer patients were collected, of which 2,282 (2.57%) patients died due to cardiovascular-related diseases. Age, chemotherapy and whether satisfactory cytoreduction surgery is still the most important factors affecting the prognosis of ovarian cancer patients, while different histological types, diagnosis time, and race also have a certain impact on the prognosis. The newly developed nomogram model showed excellent predictive performance, with a C-index of 0.759 (95%CI: 0.757-0.761) for the group. Elderly patients with ovarian cancer are still a high-risk group for cardiovascular death [HR: 21.07 (95%CI: 5.21-85.30), pā<ā0.001]. The calibration curve showed good agreement from predicted survival probabilities to actual observations.<br />Conclusion: This study found that age, histology, surgery, race, chemotherapy, and tumor metastasis are independent prognostic factors for cardiovascular death in patients with ovarian cancer. The nomogram-based model can accurately predict the OS of ovarian cancer patients. It is expected to inform clinical decision-making and help develop targeted treatment strategies for this population.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Female
Middle Aged
Aged
Nomograms
Adult
Prognosis
Risk Factors
Kaplan-Meier Estimate
Proportional Hazards Models
Aged, 80 and over
Ovarian Neoplasms mortality
Ovarian Neoplasms complications
Ovarian Neoplasms pathology
Cardiovascular Diseases mortality
Cardiovascular Diseases complications
Subjects
Details
- Language :
- English
- ISSN :
- 1757-2215
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of ovarian research
- Publication Type :
- Academic Journal
- Accession number :
- 38664732
- Full Text :
- https://doi.org/10.1186/s13048-024-01413-4