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Lemneolemnanes A-D, Four Uncommon Sesquiterpenoids from the Soft Coral Lemnalia sp.
- Source :
-
Marine drugs [Mar Drugs] 2024 Mar 26; Vol. 22 (4). Date of Electronic Publication: 2024 Mar 26. - Publication Year :
- 2024
-
Abstract
- Four undescribed sesquiterpenoids, lemneolemnanes A-D ( 1 - 4 ), have been isolated from the marine soft coral Lemnalia sp. The absolute configurations of the stereogenic carbons of 1 - 4 were determined by single-crystal X-ray crystallographic analysis. Compounds 1 and 2 are epimers at C-3 and have an unusual skeleton with a formyl group on C-6. Compound 3 possesses an uncommonly rearranged carbon skeleton, while 4 has a 6/5/5 tricyclic system. Compound 1 showed significant anti-Alzheimer's disease (AD) activity in a humanized Caenorhabditis elegans AD pathological model.
Details
- Language :
- English
- ISSN :
- 1660-3397
- Volume :
- 22
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Marine drugs
- Publication Type :
- Academic Journal
- Accession number :
- 38667762
- Full Text :
- https://doi.org/10.3390/md22040145