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Chromatin organization of muscle stem cell.
- Source :
-
Current topics in developmental biology [Curr Top Dev Biol] 2024; Vol. 158, pp. 375-406. Date of Electronic Publication: 2024 Feb 16. - Publication Year :
- 2024
-
Abstract
- The proper functioning of skeletal muscles is essential throughout life. A crucial crosstalk between the environment and several cellular mechanisms allows striated muscles to perform successfully. Notably, the skeletal muscle tissue reacts to an injury producing a completely functioning tissue. The muscle's robust regenerative capacity relies on the fine coordination between muscle stem cells (MuSCs or "satellite cells") and their specific microenvironment that dictates stem cells' activation, differentiation, and self-renewal. Critical for the muscle stem cell pool is a fine regulation of chromatin organization and gene expression. Acquiring a lineage-specific 3D genome architecture constitutes a crucial modulator of muscle stem cell function during development, in the adult stage, in physiological and pathological conditions. The context-dependent relationship between genome structure, such as accessibility and chromatin compartmentalization, and their functional effects will be analysed considering the improved 3D epigenome knowledge, underlining the intimate liaison between environmental encounters and epigenetics.<br /> (Copyright © 2024. Published by Elsevier Inc.)
- Subjects :
- Animals
Humans
Muscle, Skeletal cytology
Muscle, Skeletal growth & development
Cell Differentiation
Stem Cells cytology
Stem Cells metabolism
Epigenesis, Genetic
Muscle Development
Satellite Cells, Skeletal Muscle cytology
Satellite Cells, Skeletal Muscle metabolism
Satellite Cells, Skeletal Muscle physiology
Chromatin metabolism
Chromatin genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8933
- Volume :
- 158
- Database :
- MEDLINE
- Journal :
- Current topics in developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 38670713
- Full Text :
- https://doi.org/10.1016/bs.ctdb.2024.01.014