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Effects of Red Sorghum-Derived Deoxyanthocyanidins and Their O-β-D-Glucosides on E-Cadherin Promoter Activity in PC-3 Prostate Cancer Cells.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2024 Apr 21; Vol. 29 (8). Date of Electronic Publication: 2024 Apr 21. - Publication Year :
- 2024
-
Abstract
- Although much less common than anthocyanins, 3-Deoxyanthocyanidins (3-DAs) and their glucosides can be found in cereals such as red sorghum. It is speculated that their bioavailability is higher than that of anthocyanins. Thus far, little is known regarding the therapeutic effects of 3-DAs and their O-β-D-glucosides on cancer, including prostate cancer. Thus, we evaluated their potential to decrease cell viability, to modulate the activity of transcription factors such as NFκB, CREB, and SOX, and to regulate the expression of the gene CDH1 , encoding E-Cadherin. We found that 4',7-dihydroxyflavylium chloride (P7) and the natural apigeninidin can reduce cell viability, whereas 4',7-dihydroxyflavylium chloride (P7) and 4'-hydroxy-7-O-β-D-glucopyranosyloxyflavylium chloride (P3) increase the activities of NFkB, CREB, and SOX transcription factors, leading to the upregulation of CDH1 promoter activity in PC-3 prostate cancer cells. Thus, these compounds may contribute to the inhibition of the epithelial-to-mesenchymal transition in cancer cells and prevent the metastatic activity of more aggressive forms of androgen-resistant prostate cancer.
- Subjects :
- Humans
Male
Antigens, CD metabolism
Antigens, CD genetics
Cell Line, Tumor
Cell Survival drug effects
Gene Expression Regulation, Neoplastic drug effects
NF-kappa B metabolism
PC-3 Cells
Anthocyanins pharmacology
Anthocyanins chemistry
Cadherins drug effects
Cadherins genetics
Cadherins metabolism
Glucosides pharmacology
Glucosides chemistry
Promoter Regions, Genetic drug effects
Prostatic Neoplasms drug therapy
Prostatic Neoplasms metabolism
Prostatic Neoplasms pathology
Prostatic Neoplasms genetics
Sorghum chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 29
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 38675711
- Full Text :
- https://doi.org/10.3390/molecules29081891