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Normal or improved cardiovascular risk factors in IGF-I-deficient adults with growth hormone receptor deficiency.
- Source :
-
Med (New York, N.Y.) [Med] 2024 Jul 12; Vol. 5 (7), pp. 816-825.e4. Date of Electronic Publication: 2024 Apr 26. - Publication Year :
- 2024
-
Abstract
- Background: Human subjects with generalized growth hormone (GH) insensitivity due to GH receptor deficiency (GHRD)/Laron syndrome display a very low incidence of insulin resistance, diabetes, and cancer, as well as delayed age-related cognitive decline. However, the risk of cardiovascular disease (CVD) in these subjects is poorly understood. Here, we have assessed cardiovascular function, damage, and risk factors in GHRD subjects and their relatives.<br />Methods: We measured markers of CVD in two phases: one in a cohort of 30 individuals (GHRD = 16, control relatives = 14) brought to USC (in Los Angeles, CA) and one in a cohort including additional individuals examined in Ecuador (where the subjects live) for a total of 44 individuals (GHRD = 21, control relatives = 23). Data were collected on GHRD and control groups living in similar geographical locations and sharing comparable environmental and socio-economic circumstances.<br />Results: Compared to controls, GHRD subjects displayed lower serum glucose, insulin, blood pressure, smaller cardiac dimensions, similar pulse wave velocity, lower carotid artery intima-media thickness, lower creatinine, and a non-significant but major reduction in the portion of subjects with carotid atherosclerotic plaques (7% GHRDs vs. 36%, Controls p = 0.1333) despite elevated low-density lipoprotein cholesterol levels.<br />Conclusion: The current study indicates that individuals with GHRD have normal or improved levels of cardiovascular disease risk factors as compared to their relatives.<br />Funding: This study was funded in part by NIH/NIA grant P01 AG034906 to V.D.L.<br />Competing Interests: Declaration of interests V.D.L. has equity interest in L-Nutra, which develops and sells medical food for the prevention and treatment of diseases.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Male
Female
Adult
Middle Aged
Insulin-Like Growth Factor I metabolism
Insulin-Like Growth Factor I analysis
Insulin-Like Growth Factor I deficiency
Carotid Intima-Media Thickness
Ecuador epidemiology
Receptors, Somatotropin genetics
Receptors, Somatotropin deficiency
Pulse Wave Analysis
Risk Factors
Blood Glucose metabolism
Blood Glucose analysis
Blood Pressure
Case-Control Studies
Cardiovascular Diseases epidemiology
Laron Syndrome genetics
Heart Disease Risk Factors
Subjects
Details
- Language :
- English
- ISSN :
- 2666-6340
- Volume :
- 5
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Med (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 38677286
- Full Text :
- https://doi.org/10.1016/j.medj.2024.03.022