Diagnosis of Central Precocious Puberty.

A thorough history and physical examination including Tanner staging and growth assessments can guide differential diagnosis and aid in the evaluation of precocious puberty. Basal luteinizing hormone levels measured using a highly sensitive assay can be helpful in diagnosing central precocious puberty (CPP). Brain MRI is indicated with males diagnosed with CPP and females under the age of 6 with CPP. As more information becomes available regarding the genetic etiologies of CPP, genetic testing may preclude the need for imaging studies and other hormonal testing, especially in familial cases.
Competing Interests: Disclosure K. Bangalore Krishna has no relevant disclosures to this article. L.A. Silverman has been a consultant for Tolmar, a Data and Safety Monitoring Board member for Myovant, and with the Speaker’s Bureau for Abbvie.
(Copyright © 2024 Elsevier Inc. All rights reserved.)