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Continuous glucose monitoring for glycaemic control and cardiovascular risk reduction in patients with type 2 diabetes not on insulin therapy: A clinical trial.
- Source :
-
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2024 Jul; Vol. 26 (7), pp. 2881-2889. Date of Electronic Publication: 2024 Apr 28. - Publication Year :
- 2024
-
Abstract
- Aim: To evaluate the impact of the Dexcom G6 continuous glucose monitoring (CGM) device on glycaemic control and cardiometabolic risk in patients with type 2 diabetes mellitus (T2DM) at high cardiovascular risk who are not on insulin therapy.<br />Materials and Methods: Adults with T2DM with glycated haemoglobin (HbA1c) >7% and body mass index (BMI) ≥30 kg/m <superscript>2</superscript> not using insulin were enrolled in a two-phase cross-over study. In phase 1, CGM data were blinded, and participants performed standard glucose self-monitoring. In phase 2, the CGM data were unblinded, and CGM, demographic and cardiovascular risk factor data were collected through 90 days of follow-up and compared using paired tests.<br />Results: Forty-seven participants were included (44% women; 34% Black; mean age 63 years; BMI 37 kg/m <superscript>2</superscript> ; HbA1c 8.4%; 10-year predicted atherosclerotic cardiovascular disease risk 24.0%). CGM use was associated with a reduction in average glucose (184.0 to 147.2 mg/dl, p < .001), an increase in time in range (57.8 to 82.8%, p < .001) and a trend towards lower glucose variability (26.2 to 23.8%). There were significant reductions in HbA1c, BMI, triglycerides, blood pressure, total cholesterol, diabetes distress and 10-year predicted risk for atherosclerotic cardiovascular disease (p < .05 for all) and an increase in prescriptions for sodium-glucose cotransporter 2 inhibitors (36.2 to 83.0%) and glucagon-like peptide-1 receptor agonists (42.5 to 87.2%, p < .001 for both).<br />Conclusions: Dexcom G6 CGM was associated with improved glycaemic control and cardiometabolic risk in patients with T2DM who were not on insulin. CGM can be a safe and effective tool to improve diabetes management in patients at high risk for adverse cardiovascular outcomes.<br /> (© 2024 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.)
- Subjects :
- Humans
Female
Male
Middle Aged
Aged
Insulin therapeutic use
Heart Disease Risk Factors
Hypoglycemic Agents therapeutic use
Diabetic Angiopathies prevention & control
Diabetic Angiopathies epidemiology
Continuous Glucose Monitoring
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 complications
Blood Glucose Self-Monitoring methods
Cardiovascular Diseases prevention & control
Cardiovascular Diseases etiology
Cardiovascular Diseases epidemiology
Cross-Over Studies
Glycemic Control methods
Blood Glucose analysis
Blood Glucose metabolism
Blood Glucose drug effects
Glycated Hemoglobin analysis
Glycated Hemoglobin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1463-1326
- Volume :
- 26
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Diabetes, obesity & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 38680050
- Full Text :
- https://doi.org/10.1111/dom.15608