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Photocatalytic Thio/Selenosulfonylation-Bicyclization of Indole-Tethered 1,6-Enynes Leading to Substituted Benzo[ c ]pyrrolo[1,2,3- lm ]carbazoles.
- Source :
-
Organic letters [Org Lett] 2024 May 10; Vol. 26 (18), pp. 3828-3833. Date of Electronic Publication: 2024 Apr 29. - Publication Year :
- 2024
-
Abstract
- The photocatalyzed radical-triggered thio/selenosulfonylation-bicyclization of indole-tethered 1,6-enynes has been established for the first time, enabling the synthesis of various previously unreported thio/selenosulfonylated benzo[ c ]pyrrolo[1,2,3- lm ]carbazoles with moderate to good yields under mild conditions. The reaction pathway was proposed, consisting of energy transfer, homolytic cleavage, radical addition, 5- exo - dig , radical coupling, and a Mallory reaction cascade. This approach exhibits a wide substrate compatibility and excellent tolerability toward various functional groups and is characterized by its remarkable efficiency in both bond formation and annulation.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 26
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 38684050
- Full Text :
- https://doi.org/10.1021/acs.orglett.4c00981