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Clinicopathologic conference: Bloodstream infection in an allogeneic hamatopoietic cell transplant: Thinking beyond the usual.
- Source :
-
Transplant infectious disease : an official journal of the Transplantation Society [Transpl Infect Dis] 2024 Aug; Vol. 26 (4), pp. e14273. Date of Electronic Publication: 2024 May 02. - Publication Year :
- 2024
-
Abstract
- This case involves a 53-year-old female with concurrent acute myeloid leukemia (AML) and multiple myeloma. She underwent cytarabine and daunorubicin (7+3) induction chemotherapy followed by cytarabine (HiDAC) consolidation, with an early AML relapse requiring azacitidine and venetoclax therapy. She achieved complete remission and incomplete count recovery. Following fludarabine, melphalan, and thymoglobulin induction chemotherapy, she underwent an allogeneic stem cell transplant with failure to engraft, requiring autologous stem cell rescue, buffy coat, and granulocyte transfusions, eventually presenting with a diffuse skin rash consistent with Steven-Johnson syndrome and toxic epidermal necrolysis, persistent neutropenic fevers and positive blood cultures.<br /> (© 2024 The Authors. Transplant Infectious Disease published by Wiley Periodicals LLC.)
- Subjects :
- Humans
Middle Aged
Female
Transplantation, Homologous adverse effects
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Cytarabine therapeutic use
Cytarabine administration & dosage
Induction Chemotherapy
Leukemia, Myeloid, Acute therapy
Leukemia, Myeloid, Acute complications
Multiple Myeloma therapy
Hematopoietic Stem Cell Transplantation adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1399-3062
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Transplant infectious disease : an official journal of the Transplantation Society
- Publication Type :
- Academic Journal
- Accession number :
- 38695847
- Full Text :
- https://doi.org/10.1111/tid.14273