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Lung function trajectories from school age to adulthood and their relationship with markers of cardiovascular disease risk.
- Source :
-
Thorax [Thorax] 2024 Jul 16; Vol. 79 (8), pp. 770-777. Date of Electronic Publication: 2024 Jul 16. - Publication Year :
- 2024
-
Abstract
- Rationale: Lung function in early adulthood is associated with subsequent adverse health outcomes.<br />Objectives: To ascertain whether stable and reproducible lung function trajectories can be derived in different populations and investigate their association with objective measures of cardiovascular structure and function.<br />Methods: Using latent profile modelling, we studied three population-based birth cohorts with repeat spirometry data from childhood into early adulthood to identify trajectories of forced expiratory volume in 1 s (FEV <subscript>1</subscript> )/forced vital capacity (FVC). We used multinomial logistic regression models to investigate early-life predictors of the derived trajectories. We then ascertained the extent of the association between the derived FEV <subscript>1</subscript> /FVC trajectories and blood pressure and echocardiographic markers of increased cardiovascular risk and stroke in ~3200 participants at age 24 years in one of our cohorts.<br />Results: We identified four FEV <subscript>1</subscript> /FVC trajectories with strikingly similar latent profiles across cohorts (pooled N=6377): above average (49.5%); average (38.3%); below average (10.6%); and persistently low (1.7%). Male sex, wheeze, asthma diagnosis/medication and allergic sensitisation were associated with trajectories with diminished lung function in all cohorts. We found evidence of an increase in cardiovascular risk markers ascertained by echocardiography (including left ventricular mass indexed to height and carotid intima-media thickness) with decreasing FEV <subscript>1</subscript> /FVC (with p values for the mean crude effects per-trajectory ranging from 0.10 to p<0.001). In this analysis, we considered trajectories as a pseudo-continuous variable; we confirmed the assumption of linearity in all the regression models.<br />Conclusions: Childhood lung function trajectories may serve as predictors in the development of not only future lung disease, but also the cardiovascular disease and multimorbidity in adulthood.<br />Competing Interests: Competing interests: RG, SH, MD, AU, OM, SF, LL, AS, CP, CSM and GR declare no conflicts of interest. AS has received research grants. JWD has received research and charity grants and declares pharmaceutical support for lectures and attending conferences/meetings. AH has received support from Research Institutions and declares an unpaid fiduciary role. JWH has received research grant and support for travel to congress. AC has received research grants, consulting fees, honoraria for lectures and declares unpaid fiduciary role.<br /> (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.)
- Subjects :
- Humans
Male
Female
Child
Adolescent
Vital Capacity physiology
Forced Expiratory Volume physiology
Young Adult
Spirometry
Asthma physiopathology
Asthma epidemiology
Echocardiography
Heart Disease Risk Factors
Lung physiopathology
Lung diagnostic imaging
Adult
Risk Factors
Cardiovascular Diseases physiopathology
Cardiovascular Diseases epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1468-3296
- Volume :
- 79
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Thorax
- Publication Type :
- Academic Journal
- Accession number :
- 38697843
- Full Text :
- https://doi.org/10.1136/thorax-2023-220485