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Changes in depressive symptoms and antibody production following influenza vaccination in adolescents and adults.
- Source :
-
Vaccine [Vaccine] 2024 Jun 11; Vol. 42 (16), pp. 3585-3591. Date of Electronic Publication: 2024 May 03. - Publication Year :
- 2024
-
Abstract
- Objective: Psychological distress has been associated with dampened antibody production following vaccination. Questions remain, however, about whether psychological distress influences vaccine response uniformly across the lifespan, and whether changes in distress result in changes in antibody production across the same period.<br />Methods: Participants (N = 148; M <subscript>age</subscript>  = 32.2 years, SD = 19.7, range = 12-80 years) took part in consecutive vaccine studies during the 2017-2018 and 2018-2019 influenza seasons. Each influenza season, they reported on their depressive symptoms, provided blood samples, and received the standard influenza vaccine. Participants then provided a second blood sample one month later. Antibody titers were examined pre- and post-vaccination.<br />Results: Analyses examined both within-season and across-season effects of depressive symptoms, age, and their interaction on vaccine response. Within-season analyses revealed that age predicted antibody response during both seasons (2017-2018 and 2018-2019). Neither depressive symptoms nor the interaction with age were associated with antibody response to vaccination within either season. Across the two seasons, age significantly moderated the association between change in depressive symptoms and change in antibody production. For people who were 48 or older, increases in depressive symptoms across the two seasons were associated with a less robust response to the vaccine in the second season relative to the first season. For people younger than 48, changes in depressive symptoms were not significantly related to changes in antibody production.<br />Conclusions: These findings highlight the important role of mental health for older adults' vaccine response, which could have clinical relevance for protection against disease.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024. Published by Elsevier Ltd.)
- Subjects :
- Humans
Adolescent
Adult
Male
Female
Young Adult
Middle Aged
Aged
Aged, 80 and over
Child
Seasons
Influenza Vaccines immunology
Influenza Vaccines administration & dosage
Depression immunology
Influenza, Human prevention & control
Influenza, Human immunology
Antibodies, Viral blood
Vaccination psychology
Antibody Formation immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 42
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 38702230
- Full Text :
- https://doi.org/10.1016/j.vaccine.2024.04.066