Back to Search
Start Over
Does depressurization of the portal vein before liver transplantation affect the recurrence of HCC? A nested case-control study.
- Source :
-
BMC cancer [BMC Cancer] 2024 May 03; Vol. 24 (1), pp. 558. Date of Electronic Publication: 2024 May 03. - Publication Year :
- 2024
-
Abstract
- Background: Portal hypertension (PHT) has been proven to be closely related to the development of hepatocellular carcinoma (HCC). Whether PHT before liver transplantation (LT) will affect the recurrence of HCC is not clear.<br />Methods: 110 patients with depressurization of the portal vein (DPV) operations (Transjugular Intrahepatic Portosystemic Shunt-TIPS, surgical portosystemic shunt or/and splenectomy) before LT from a HCC LT cohort, matched with 330 preoperative non-DPV patients; this constituted a nested case-control study. Subgroup analysis was based on the order of DPV before or after the occurrence of HCC.<br />Results: The incidence of acute kidney injury and intra-abdominal bleeding after LT in the DPV group was significantly higher than that in non-DPV group. The 5-year survival rates in the DPV and non-DPV group were 83.4% and 82.7% respectively (P = 0.930). In subgroup analysis, patients in the DPV prior to HCC subgroup may have a lower recurrence rate (4.7% vs.16.8%, P = 0.045) and a higher tumor free survival rate (88.9% vs.74.4%, P = 0.044) after LT under the up-to-date TNMI-II stage, while in TNM III stage, there was no difference for DPV prior to HCC subgroup compared with the DPV after HCC subgroup or the non-DPV group.<br />Conclusion: Compared with DPV after HCC, DPV treatment before HCC can reduce the recurrence rate of HCC after early transplantation (TNM I-II). DPV before LT can reduce the recurrence of early HCC.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Female
Middle Aged
Case-Control Studies
Aged
Adult
Liver Transplantation adverse effects
Carcinoma, Hepatocellular surgery
Carcinoma, Hepatocellular pathology
Carcinoma, Hepatocellular mortality
Portal Vein pathology
Portal Vein surgery
Liver Neoplasms surgery
Liver Neoplasms pathology
Liver Neoplasms mortality
Neoplasm Recurrence, Local epidemiology
Neoplasm Recurrence, Local pathology
Hypertension, Portal surgery
Hypertension, Portal complications
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 38702621
- Full Text :
- https://doi.org/10.1186/s12885-024-12322-6