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Milk Fat Globule Proteins Are Relevant Bovine Milk Allergens in Patients with α‐Gal Syndrome.
- Source :
-
Molecular nutrition & food research [Mol Nutr Food Res] 2024 May; Vol. 68 (10), pp. e2300796. Date of Electronic Publication: 2024 May 05. - Publication Year :
- 2024
-
Abstract
- Alpha-gal syndrome (AGS) is a mammalian meat allergy associated with tick bites and specific IgE to the oligosaccharide galactose-α-1,3-galactose (α-gal). Recent studies have shown that 10-20% of AGS patients also react to the dairy proteins. Considering the already described role of the meat lipid fraction in AGS manifestations, the aim of this work has been to investigate whether the milk fat globule proteins (MFGPs) could be involved in AGS. The MFGPs are extracted and their recognition by the IgE of AGS patients is proved through immunoblotting experiments. The identification of the immunoreactive proteins by LC-HRMS analysis allows to demonstrate for the first time that butyrophillin, lactadherin, and xanthine oxidase (XO) are α-gal glycosylated. The role of xanthine oxidase seems to be prevalent since it is highly recognized by both the anti-α-gal antibody and AGS patient sera. The results obtained in this study provide novel insights in the characterization of α-Gal carrying glycoproteins in bovine milk, supporting the possibility that milk, especially in its whole form, may give reactions in AGS patients. Although additional factors are probably associated with the clinical manifestations, the avoidance of milk and milk products should be considered in individuals with AGS showing symptoms related to milk consumption.<br /> (© 2024 Wiley‐VCH GmbH.)
- Subjects :
- Humans
Animals
Cattle
Allergens immunology
Butyrophilins metabolism
Female
Milk Proteins immunology
Immunoglobulin E immunology
Food Hypersensitivity immunology
Tick Bites
Adult
Male
Antigens, Surface immunology
Middle Aged
alpha-Galactosidase
Disaccharides
Glycoproteins
Lipid Droplets
Glycolipids
Milk chemistry
Subjects
Details
- Language :
- German
- ISSN :
- 1613-4133
- Volume :
- 68
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Molecular nutrition & food research
- Publication Type :
- Academic Journal
- Accession number :
- 38704747
- Full Text :
- https://doi.org/10.1002/mnfr.202300796