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The impact of IDR phosphorylation on the RNA binding profiles of proteins.

Authors :
Modic M
Adamek M
Ule J
Source :
Trends in genetics : TIG [Trends Genet] 2024 Jul; Vol. 40 (7), pp. 580-586. Date of Electronic Publication: 2024 May 04.
Publication Year :
2024

Abstract

Due to their capacity to mediate repetitive protein interactions, intrinsically disordered regions (IDRs) are crucial for the formation of various types of protein-RNA complexes. The functions of IDRs are strongly modulated by post-translational modifications (PTMs). Phosphorylation is the most common and well-studied modification of IDRs, which can alter homomeric or heteromeric interactions of proteins and impact their ability to phase separate. Moreover, phosphorylation can influence the RNA-binding properties of proteins, and recent studies demonstrated its selective impact on the global profiles of protein-RNA binding and regulation. These findings highlight the need for further integrative approaches to understand how signalling remodels protein-RNA networks in cells.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
0168-9525
Volume :
40
Issue :
7
Database :
MEDLINE
Journal :
Trends in genetics : TIG
Publication Type :
Academic Journal
Accession number :
38705823
Full Text :
https://doi.org/10.1016/j.tig.2024.04.004