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The impact of IDR phosphorylation on the RNA binding profiles of proteins.
- Source :
-
Trends in genetics : TIG [Trends Genet] 2024 Jul; Vol. 40 (7), pp. 580-586. Date of Electronic Publication: 2024 May 04. - Publication Year :
- 2024
-
Abstract
- Due to their capacity to mediate repetitive protein interactions, intrinsically disordered regions (IDRs) are crucial for the formation of various types of protein-RNA complexes. The functions of IDRs are strongly modulated by post-translational modifications (PTMs). Phosphorylation is the most common and well-studied modification of IDRs, which can alter homomeric or heteromeric interactions of proteins and impact their ability to phase separate. Moreover, phosphorylation can influence the RNA-binding properties of proteins, and recent studies demonstrated its selective impact on the global profiles of protein-RNA binding and regulation. These findings highlight the need for further integrative approaches to understand how signalling remodels protein-RNA networks in cells.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Subjects :
- Phosphorylation
Humans
RNA-Binding Proteins genetics
RNA-Binding Proteins metabolism
RNA metabolism
RNA genetics
Protein Processing, Post-Translational genetics
Intrinsically Disordered Proteins metabolism
Intrinsically Disordered Proteins genetics
Intrinsically Disordered Proteins chemistry
Protein Binding
Subjects
Details
- Language :
- English
- ISSN :
- 0168-9525
- Volume :
- 40
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Trends in genetics : TIG
- Publication Type :
- Academic Journal
- Accession number :
- 38705823
- Full Text :
- https://doi.org/10.1016/j.tig.2024.04.004