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Lethal Capecitabine Toxicity in Patients With Complete Dihydropyrimidine Dehydrogenase Deficiency Due to Ultra-Rare DPYD Variants.

Authors :
van Kuilenburg ABP
Pleunis-van Empel MCH
Brouwer RB
Sijben AEJ
Knapen DG
Oude Munnink TH
van Zanden JJ
Janssens-Puister J
Dobritzsch D
Meinsma R
Meijer-Jansen J
van Dooren SJM
Vijzelaar R
Pop A
Salomons GS
Maring JG
Niezen-Koning KE
Source :
JCO precision oncology [JCO Precis Oncol] 2024 May; Vol. 8, pp. e2300599.
Publication Year :
2024

Abstract

A DPD deficiency should be considered in case of severe toxicity even in the absence of common risk variants in DPYD.

Details

Language :
English
ISSN :
2473-4284
Volume :
8
Database :
MEDLINE
Journal :
JCO precision oncology
Publication Type :
Academic Journal
Accession number :
38709992
Full Text :
https://doi.org/10.1200/PO.23.00599