A novel dual near-infrared fluorescent probe for bioimaging and visualization of viscosity in acute alcoholic liver injury.

Authors :: Wang R
Zhou X
Li B
Ding R
Han J
Wang Y
Meng A
Zhou J
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 May 30; Vol. 60 (45), pp. 5804-5807. Date of Electronic Publication: 2024 May 30.
Publication Year :: 2024
Abstract: A dual NIR fluorescent probe Cy-ND is developed for viscosity sensing with λ <subscript>ex/em</subscript> = 766/806 nm, making it apt for biological analysis, whose response is validated through DFT and TDDFT computations. Cy-ND successfully detected viscosity changes amidst acute alcohol-induced liver injury and liver ischemia-reperfusion injury.

Subjects :: Viscosity
Animals
Optical Imaging
Humans
Mice
Density Functional Theory
Liver diagnostic imaging
Liver Diseases, Alcoholic diagnostic imaging
Reperfusion Injury diagnostic imaging
Carbocyanines chemistry
Fluorescent Dyes chemistry
Fluorescent Dyes chemical synthesis

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