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Antimalarial 9-methoxystrobilurin derivatives from cultures of the basidiomycete Favolaschia minutissima.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2024 Jul; Vol. 77 (7), pp. 422-427. Date of Electronic Publication: 2024 May 09. - Publication Year :
- 2024
-
Abstract
- Investigation of cultures of the basidiomycete Favolaschia minutissima TBRC-BCC 19434 led to the isolation of two undescribed β-methoxyacrylate metabolites, 9-methoxystrobilurins R (1) and S (2), and a degraded aldehyde derivative, favodehyde E (3). 9-Methoxystrobilurin derivatives 1 and 2 exhibited significant antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with IC <subscript>50</subscript> values of 0.12 and 0.21 μM, respectively.<br /> (© 2024. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.)
- Subjects :
- Inhibitory Concentration 50
Basidiomycota chemistry
Basidiomycota metabolism
Acrylates pharmacology
Acrylates chemistry
Molecular Structure
Antimalarials pharmacology
Antimalarials isolation & purification
Antimalarials chemistry
Plasmodium falciparum drug effects
Strobilurins pharmacology
Strobilurins chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1881-1469
- Volume :
- 77
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 38724629
- Full Text :
- https://doi.org/10.1038/s41429-024-00733-3