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Bilaterally Aligned Electroosmotic Flow Generated by Porous Microneedle Device for Dual-Mode Delivery.
- Source :
-
Advanced healthcare materials [Adv Healthc Mater] 2024 Sep; Vol. 13 (22), pp. e2401181. Date of Electronic Publication: 2024 May 17. - Publication Year :
- 2024
-
Abstract
- Here, a novel porous microneedle (PMN) device with bilaterally aligned electroosmotic flow (EOF) enabling controllable dual-mode delivery of molecules is developed. The PMNs placed at anode and cathode compartments are modified with anionic poly-2-acrylamido-2-methyl-1-propanesulfonic acid and cationic poly-(3-acrylamidopropyl) trimethylammonium, respectively. The direction of EOF generated by PMN at the cathode compartment is, therefore, reversed from cathode to anode, countering the unwanted cathodal suctioning of interstitial fluid caused by reverse iontophoresis. With the bilateral alignment of EOF, the versatility of the proposed device is evaluated by delivering molecules with different charges and sizes using Franz cell. In addition, a 3D printed probe device is developed to ease practical handling and minimize electrical stimulation by integrating two PMNs in closed proximity. Finally, the performance of the integrated probe device is demonstrated by dual delivery of a variety of molecules (methylene blue, rhodamine B, and fluorescein isothiocyanate-dextran) using pig skin and vaccination using mice with delivered ovalbumin.<br /> (© 2024 The Authors. Advanced Healthcare Materials published by Wiley‐VCH GmbH.)
- Subjects :
- Animals
Swine
Mice
Porosity
Fluorescein-5-isothiocyanate analogs & derivatives
Fluorescein-5-isothiocyanate chemistry
Dextrans chemistry
Methylene Blue chemistry
Ovalbumin administration & dosage
Ovalbumin chemistry
Drug Delivery Systems instrumentation
Drug Delivery Systems methods
Skin metabolism
Microinjections instrumentation
Microinjections methods
Printing, Three-Dimensional
Needles
Electroosmosis instrumentation
Rhodamines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2192-2659
- Volume :
- 13
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Advanced healthcare materials
- Publication Type :
- Academic Journal
- Accession number :
- 38734966
- Full Text :
- https://doi.org/10.1002/adhm.202401181