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Aluminium Chloride instead of Ferric chloride for inducing superior sagittal sinus thrombosis to reduce ferromagnetic artifacts on MRI-imaging in experimental models.
- Source :
-
Scientific reports [Sci Rep] 2024 May 14; Vol. 14 (1), pp. 10998. Date of Electronic Publication: 2024 May 14. - Publication Year :
- 2024
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Abstract
- Using ferric chloride (FeCl3) to induce experimental superior sagittal sinus (SSS) thrombosis might interfere with magnetic resonance imaging (MRI)-assisted visualization and evaluation of the thrombus, the brain parenchyma, and the quality of the occlusion. The aim of this study was to investigate whether aluminum chloride (AlCl3)-induced thrombosis of the SSS has comparable properties to those of FeCl3 without causing artifacts in MRI. SSS thrombosis was induced in 14 male Wistar rats by exposure of the SSS and subsequent topical application of a filter paper strip soaked in AlCl3 (n = 7) or FeCl3 (n = 7) over a period of 15 min. The animals with AlCl3-induced SSS thrombosis showed a constant and complete occlusion with in histological analysis large thrombi. Blood flow measurements indicated a significant reduction on the first and seventh postoperative day compared to preoperative measurements. MRI enabled visualization and subsequent evaluation of the thrombus and the surrounding parenchyma. In comparison, FeCl3-induced SSS thrombosis could not be evaluated by MRI due to artifacts caused by the paramagnetic properties and increased susceptibility of FeCl3. The occluded sinus and the surrounding area appeared hypointense. The quality of SSS occlusion by AlCl3 was comparable to that of FeCl3. AlCl3 therefore represents a significant alternative substance in experimental SSS thrombosis ideally suited for studies using MRI.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Male
Rats
Sagittal Sinus Thrombosis diagnostic imaging
Sagittal Sinus Thrombosis chemically induced
Aluminum Compounds
Superior Sagittal Sinus diagnostic imaging
Superior Sagittal Sinus drug effects
Aluminum Chloride
Ferric Compounds
Magnetic Resonance Imaging methods
Rats, Wistar
Artifacts
Chlorides pharmacology
Chlorides administration & dosage
Disease Models, Animal
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 38745068
- Full Text :
- https://doi.org/10.1038/s41598-024-61885-8