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Endobronchial Phenylephrine in Airway Bleeding During Bronchoscopy Does not Cause Hypertension: A Retrospective Observational Study.
- Source :
-
Journal of bronchology & interventional pulmonology [J Bronchology Interv Pulmonol] 2024 May 15; Vol. 31 (3). Date of Electronic Publication: 2024 May 15 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Background: Bleeding is a known complication during bronchoscopy, with increased incidence in patients undergoing a more invasive procedure. Phenylephrine is a potent vasoconstrictor that can control airway bleeding when applied topically and has been used as an alternative to epinephrine. The clinical effects of endobronchial phenylephrine on systemic vasoconstriction have not been clearly evaluated. Here, we compared the effects of endobronchial phenylephrine versus cold saline on systemic blood pressure.<br />Methods: In all, 160 patients who underwent bronchoscopy and received either endobronchial phenylephrine or cold saline from July 1, 2017 to June 30, 2022 were included in this retrospective observational study. Intra-procedural blood pressure absolute and percent changes were measured and compared between the 2 groups.<br />Results: There were no observed statistical differences in blood pressure changes between groups. The median absolute change between the median and the maximum intra-procedural systolic blood pressure in the cold saline group was 29 mm Hg (IQR 19 to 41) compared with 31.8 mm Hg (IQR 18 to 45.5) in the phenylephrine group. The corresponding median percent changes in SBP were 33.6 % (IQR 18.8 to 39.4) and 28% (IQR 16.8 to 43.5) for the cold saline and phenylephrine groups, respectively. Similarly, there were no statistically significant differences in diastolic and mean arterial blood pressure changes between both groups.<br />Conclusions: We found no significant differences in median intra-procedural systemic blood pressure changes comparing patients who received endobronchial cold saline to those receiving phenylephrine. Overall, this argues for the vascular and systemic safety of phenylephrine for airway bleeding as a reasonable alternative to epinephrine.<br />Competing Interests: Disclosure: The authors declare no conflicts of interest.<br /> (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
- Subjects :
- Humans
Retrospective Studies
Male
Female
Middle Aged
Aged
Hypertension drug therapy
Blood Pressure drug effects
Phenylephrine administration & dosage
Phenylephrine adverse effects
Bronchoscopy adverse effects
Bronchoscopy methods
Vasoconstrictor Agents administration & dosage
Vasoconstrictor Agents adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1948-8270
- Volume :
- 31
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of bronchology & interventional pulmonology
- Publication Type :
- Academic Journal
- Accession number :
- 38745445
- Full Text :
- https://doi.org/10.1097/LBR.0000000000000968