Back to Search Start Over

The biology and pathogenesis of vivax malaria.

Authors :
Anstey NM
Tham WH
Shanks GD
Poespoprodjo JR
Russell BM
Kho S
Source :
Trends in parasitology [Trends Parasitol] 2024 Jul; Vol. 40 (7), pp. 573-590. Date of Electronic Publication: 2024 May 15.
Publication Year :
2024

Abstract

Plasmodium vivax contributes significantly to global malaria morbidity. Key advances include the discovery of pathways facilitating invasion by P. vivax merozoites of nascent reticulocytes, crucial for vaccine development. Humanized mouse models and hepatocyte culture systems have enhanced understanding of hypnozoite biology. The spleen has emerged as a major reservoir for asexual vivax parasites, replicating in an endosplenic life cycle, and contributing to recurrent and chronic infections, systemic inflammation, and anemia. Splenic accumulation of uninfected red cells is the predominant cause of anemia. Recurring and chronic infections cause progressive anemia, malnutrition, and death in young children in high-transmission regions. Endothelial activation likely contributes to vivax-associated organ dysfunction. The many recent advances in vivax pathobiology should help guide new approaches to prevention and management.<br />Competing Interests: Declaration of interests G.D.S. is an unpaid consultant to GSK on tafenoquine. All other authors declare no competing interests.<br /> (Crown Copyright © 2024. Published by Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1471-5007
Volume :
40
Issue :
7
Database :
MEDLINE
Journal :
Trends in parasitology
Publication Type :
Academic Journal
Accession number :
38749866
Full Text :
https://doi.org/10.1016/j.pt.2024.04.015