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Peptide spiders are emerging as novel therapeutic interventions for nucleic acid delivery.

Authors :
Rahman M
Sahoo A
Almalki WH
Almujri SS
Altamimi ASA
Alhamyani A
Akhter S
Source :
Drug discovery today [Drug Discov Today] 2024 Jul; Vol. 29 (7), pp. 104021. Date of Electronic Publication: 2024 May 17.
Publication Year :
2024

Abstract

The FDA has approved many nucleic acid (NA)-based products. The presence of charges and biological barriers however affect stability and restrict widespread use. The electrostatic complexation of peptide with polyethylene glycol-nucleic acids (PEG-NAs) via nonreducible and reducible agents lead to three parts at one platform.. The reducible linkage made detachment of siRNA from PEG easy compared with a nonreducible linkage. A peptide spider produces a small hydrodynamic particle size, which can improve drug release and pharmacokinetics. Several examples of peptide spiders that enhance stability, protection and transfection efficiency are discussed. Moreover, this review also covers the challenges, future perspectives and unmet needs of peptide-PEG-NAs conjugates for NAs delivery.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1878-5832
Volume :
29
Issue :
7
Database :
MEDLINE
Journal :
Drug discovery today
Publication Type :
Academic Journal
Accession number :
38750928
Full Text :
https://doi.org/10.1016/j.drudis.2024.104021