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Posterior Segment Manifestations of Syphilis and Correlation With Serologic Markers of Infection.

Authors :
Rickels KL
Jabbehdari S
Krishnan VJ
Chauhan MZ
Ji MH
Tetelbom PS
Sallam AB
Chacko JG
Mansour AM
Uwaydat SH
Source :
Ophthalmic surgery, lasers & imaging retina [Ophthalmic Surg Lasers Imaging Retina] 2024 Sep; Vol. 55 (9), pp. 511-516. Date of Electronic Publication: 2024 May 01.
Publication Year :
2024

Abstract

Background and Objective: Retrospective analysis correlating serologic titers of ocular syphilis with posterior segment manifestations.<br />Patients and Methods: This study consisted of 40 patients (80 eyes imaged, 68 affected) with positive rapid plasma reagin (RPR) and Treponema Pallidum immunoglobulin G. We collected demographic and presentation data including HIV status, absolute CD4 count, RPR, cerebrospinal fluid-venereal disease research laboratory (CSF-VDRL) test, and retinal zone. We categorized imaging into syphilitic outer retinopathy (SOR), acute syphilitic posterior placoid chorioretinopathy, retinitis/chorioretinitis (RC), and papillitis. Multivariate analysis correlated HIV status, RPR, and VDRL titers with posterior segment findings and zone.<br />Results: Mean age of 42.8 ± 10.7 years, with 70% male patients. Presenting visual acuity (logMAR) 0.66 ± 0.74 did not correlate with RPR, nor was it associated with papillitis, RC, or acute syphilitic posterior placoid chorioretinopathy. Higher RPR (≥ 1:128) positively associated with SOR ( P = 0.031) and zone 1 (odds ratio [OR], 1.62; P = 0.02), but negatively associated with zone 2 (OR 0.35; P = 0.005). HIV positivity increased RC odds (OR, 4.45; P = 0.047).<br />Conclusion: Higher RPR correlated with SOR and zone 1, whereas HIV positivity correlated with RC. [ Ophthalmic Surg Lasers Imaging Retina 2024;55:511-516.] .

Details

Language :
English
ISSN :
2325-8179
Volume :
55
Issue :
9
Database :
MEDLINE
Journal :
Ophthalmic surgery, lasers & imaging retina
Publication Type :
Academic Journal
Accession number :
38752914
Full Text :
https://doi.org/10.3928/23258160-20240411-03