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Supplementation with organic yeast-derived selenium provides immune protection against experimental necrotic enteritis in broiler chickens.
- Source :
-
Microbial pathogenesis [Microb Pathog] 2024 Jul; Vol. 192, pp. 106691. Date of Electronic Publication: 2024 May 15. - Publication Year :
- 2024
-
Abstract
- Necrotic enteritis (NE) is a potentially fatal poultry disease that causes enormous economic losses in the poultry industry worldwide. The study aimed to evaluate the effects of dietary organic yeast-derived selenium (Se) on immune protection against experimental necrotic enteritis (NE) in commercial broilers. Chickens were fed basal diets supplemented with different Se levels (0.25, 0.50, and 1.00 Se mg/kg). To induce NE, Clostridium perfringens (C. perfringens) was orally administered at 14 days of age post hatch. The results showed that birds fed 0.25 Se mg/kg exhibited significantly increased body weight gain compared with the non-supplemented/infected birds. There were no significant differences in gut lesions between the Se-supplemented groups and the non-supplemented group. The antibody levels against α-toxin and NetB toxin increased with the increase between 0.25 Se mg/kg and 0.50 Se mg/kg. In the jejunal scrapings and spleen, the Se-supplementation groups up-regulated the transcripts for pro-inflammatory cytokines IL-1β, IL-6, IL-8, iNOS, and LITAF and avian β-defensin 6, 8, and 13 (AvBD6, 8 and 13). In conclusion, supplementation with organic yeast-derived Se alleviates the negative consequences and provides beneficial protection against experimental NE.<br />Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Meiyu Zhang, Zehai Yu, Jian Liu, Zhiyuan Chen, Jiehua Yang, Yanbo Yin and Shouzhen Xu reports financial support was provided by The Industry Innovation Team of the Modern Agricultural Technology System of Shandong Province. Shouzhen Xu reports a relationship with The Industry Innovation Team of the Modern Agricultural Technology System of Shandong Province that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Bacterial Toxins immunology
Necrosis
beta-Defensins metabolism
Jejunum drug effects
Jejunum immunology
Jejunum microbiology
Jejunum pathology
Spleen immunology
Yeasts
Nitric Oxide Synthase Type II metabolism
Interleukin-6 metabolism
Interleukin-8 metabolism
Interleukin-1beta metabolism
Antibodies, Bacterial blood
Chickens
Enteritis prevention & control
Enteritis veterinary
Enteritis immunology
Enteritis microbiology
Selenium pharmacology
Selenium administration & dosage
Poultry Diseases prevention & control
Poultry Diseases immunology
Dietary Supplements
Clostridium perfringens immunology
Clostridium Infections prevention & control
Clostridium Infections veterinary
Clostridium Infections immunology
Animal Feed
Cytokines metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1096-1208
- Volume :
- 192
- Database :
- MEDLINE
- Journal :
- Microbial pathogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 38759933
- Full Text :
- https://doi.org/10.1016/j.micpath.2024.106691