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Zinc(II) coordination compound with N'-(pyridin-2-ylmethylene)nicotinohydrazide: Synthesis, crystal structure, computational and cytotoxicity studies.
- Source :
-
Journal of inorganic biochemistry [J Inorg Biochem] 2024 Aug; Vol. 257, pp. 112598. Date of Electronic Publication: 2024 May 08. - Publication Year :
- 2024
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Abstract
- In this work, we report on the synthesis of a novel zinc(II) coordination compound [ZnL <subscript>2</subscript> ] (1), which was readily obtained from the reaction of Zn(OAc)·2H <subscript>2</subscript> O and N'-(pyridin-2-ylmethylene)nicotinohydrazide (HL) in methanol. Recrystallization of 1 from dimethylformamide under ambient conditions allowed to produce yellow block-like crystals of 1·H <subscript>2</subscript> O. Complex 1·H <subscript>2</subscript> O was characterized by FT-IR and <superscript>1</superscript> H NMR spectroscopy, while its optical properties were studied by UV-vis and spectrofluorimetry in methanol. The crystal structure of the title complex was revealed by single crystal X-ray diffraction and further explored in detail by the Hirshfeld surface analysis. Theoretical investigations based on the DFT calculations have also been applied to show the electronic properties of complex 1. The antitumor activities of the parent ligand HL and complex 1 were studied using Dalton's lymphoma malignant cancer model. Both compounds were found to induce concentration-dependent cytotoxicity and apoptotic cell death, leading to a decrease in cell viability, body weight, and tumor volume in mice with the superior activity of complex 1 over HL. Mice treated with complex 1 demonstrated an increase in life span with a survival period of 23 days. Finally, using a molecular docking approach, we have probed complex 1 to inhibit the recombinant mouse tumor-necrosis factor alpha (mTNF).<br />Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Mice
Humans
Crystallography, X-Ray
Cell Line, Tumor
Apoptosis drug effects
Cell Survival drug effects
Zinc chemistry
Coordination Complexes pharmacology
Coordination Complexes chemical synthesis
Coordination Complexes chemistry
Antineoplastic Agents pharmacology
Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3344
- Volume :
- 257
- Database :
- MEDLINE
- Journal :
- Journal of inorganic biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38763101
- Full Text :
- https://doi.org/10.1016/j.jinorgbio.2024.112598