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The association of depressive symptoms with adverse clinical outcomes in hypertension: Data from SPRINT randomized trail.
- Source :
-
Journal of affective disorders [J Affect Disord] 2024 Aug 15; Vol. 359, pp. 59-69. Date of Electronic Publication: 2024 May 18. - Publication Year :
- 2024
-
Abstract
- Objective: This study intends to explore the effect of depressive symptoms on adverse clinical outcomes in middle-aged and elderly hypertensive patients.<br />Methods: This post hoc analysis was conducted using data from the Systolic Blood Pressure Intervention Trial (SPRINT), and we used cox proportional risk regression to examine the relationship between depressive symptoms and adverse clinical outcomes (primary outcome, all-cause mortality, cardiovascular disease(CVD) mortality, heart failure(HF), myocardial infarction(MI), non-myocardial infarction acute coronary syndrome(non-MI ACS)).<br />Results: In a follow-up study of 9259 participants, we found that depression symptoms was significantly and positively associated with the primary outcome (HR 1.03, 95%CI 1.01-1.05; p for trend = 0.0038), all-cause mortality (HR 1.03, 95%CI 1.01-1.05; p for trend = 0.0308), HF(HR 1.05, 95%CI 1.01-1.08; p for trend = 0.0107), and non-MI ACS(HR 1.06, 95%CI 1.01-1.10; p for trend = 0.0120). Kaplan-Meier survival curves for depression symptoms severity (none, mild, moderate, and above) and adverse clinical outcomes suggested that for all but primary clinical outcomes, the cumulative risk of adverse clinical outcomes increased with increasing depression symptoms severity.<br />Conclusion: For middle-aged and elderly hypertensive patients, depression symptoms exacerbates the risk of adverse clinical outcomes (primary outcome, all-cause mortality, CVD death, MI, HF, and non-MI ACS), and the risk increases with the severity of depression symptoms.<br />Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Ning Ding reports financial support was provided by Changsha Natural Science Foundation (kq2208445), Changsha Central Hospital (YNKY202306), Changsha Science and Technology Bureau (kzd22074, kzd22075). If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024. Published by Elsevier B.V.)
- Subjects :
- Humans
Female
Male
Middle Aged
Aged
Heart Failure mortality
Follow-Up Studies
Cardiovascular Diseases mortality
Cardiovascular Diseases epidemiology
Proportional Hazards Models
Acute Coronary Syndrome mortality
Acute Coronary Syndrome complications
Acute Coronary Syndrome psychology
Hypertension epidemiology
Depression epidemiology
Myocardial Infarction mortality
Myocardial Infarction psychology
Myocardial Infarction epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2517
- Volume :
- 359
- Database :
- MEDLINE
- Journal :
- Journal of affective disorders
- Publication Type :
- Academic Journal
- Accession number :
- 38768819
- Full Text :
- https://doi.org/10.1016/j.jad.2024.05.079