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Association of sodium-glucose cotransporter 2 inhibitor use with risk of osteoporotic fracture among older women: A nationwide, population-based cohort study.
- Source :
-
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2024 Jul; Vol. 213, pp. 111712. Date of Electronic Publication: 2024 May 18. - Publication Year :
- 2024
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Abstract
- Introduction: We investigated the relationship between sodium-glucose cotransporter-2 inhibitor (SGLT2i) and fracture in elderly women diagnosed with type 2 diabetes mellitus (T2DM) and newly prescribed antidiabetic medications (ADMs).<br />Material and Methods: We used the population-based cohort study data from the National Health Insurance Service of Korea (2013-2020). Women ≥65 years old with T2DM, who were newly prescribed ADMs other than glucagon-like peptide-1 receptor agonists and thiazolidinedione, and who had comprehensive health check-up data were included.<br />Results: A total of 1,333 SGLT2i users were matched in a 1:2 ratio with 2,626 non-SGLT2i users. After propensity score matching, mean age, body mass index, number of ADMs, and other covariates were well-balanced between SGLT2i users and non-SGLT2i users. During the follow-up period, a higher incidence of vertebral fractures in SGLT2i users than in non-SGLT2i users (incidence rate 19.2 vs. 13.8 per 1,000 person-years; hazard ratio 1.40, 95 % confidence interval 1.00-1.96, p = 0.049). No significant difference was noted in other types of fracture.<br />Conclusion: SGLT2i use showed an increased risk of vertebral fracture than non-SGLT2i use in elderly women. Although further validation is required, SGLT2i should be cautiously prescribed in older women due to the potential association with fracture risk.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024. Published by Elsevier B.V.)
- Subjects :
- Humans
Female
Aged
Republic of Korea epidemiology
Cohort Studies
Aged, 80 and over
Incidence
Risk Factors
Hypoglycemic Agents adverse effects
Hypoglycemic Agents therapeutic use
Spinal Fractures epidemiology
Spinal Fractures chemically induced
Sodium-Glucose Transporter 2 Inhibitors adverse effects
Sodium-Glucose Transporter 2 Inhibitors therapeutic use
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 epidemiology
Osteoporotic Fractures epidemiology
Osteoporotic Fractures chemically induced
Osteoporotic Fractures prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8227
- Volume :
- 213
- Database :
- MEDLINE
- Journal :
- Diabetes research and clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 38768867
- Full Text :
- https://doi.org/10.1016/j.diabres.2024.111712