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Enhancing Infected Diabetic Wound Healing through Multifunctional Nanocomposite-Loaded Microneedle Patch: Inducing Multiple Regenerative Sites.
- Source :
-
Advanced healthcare materials [Adv Healthc Mater] 2024 Aug; Vol. 13 (20), pp. e2301985. Date of Electronic Publication: 2024 Jun 03. - Publication Year :
- 2024
-
Abstract
- Infected diabetic wound (DW) presents a prolonged and challenging healing process within the field of regenerative medicine. The effectiveness of conventional drug therapies is hindered by their limited ability to reach deep tissues and promote adequate wound healing rates. Therefore, there is an imperative to develop drug delivery systems that can penetrate deep tissues while exhibiting multifunctional properties to expedite wound healing. In this study, w e devised a soluble microneedle (MN) patch made of γ-PGA, featuring multiple arrays, which w as loaded with core-shell structured nanoparticles (NPs) known as Ag@MSN@CeO <subscript>2</subscript> , to enhance the healing of infected DWs. The NP comprises a cerium dioxide (CeO <subscript>2</subscript> ) core with anti-inflammatory and antioxidant properties, a mesoporous silica NP (MSN) shell with angiogenic characteristics, and an outermost layer doped with Ag to combat bacterial infections. W e demonstrated that the MN platform loaded with Ag@MSN@CeO <subscript>2</subscript> successfully penetrated deep tissues for effective drug delivery. These MN tips induced the formation of multiple regenerative sites at various points, leading to antibacterial, reactive oxygen species-lowering, macrophage ecological niche-regulating, vascular regeneration-promoting, and collagen deposition-promoting effects, thus significantly expediting the healing process of infected DWs. Considering these findings, the multifunctional MN@Ag@MSN@CeO <subscript>2</subscript> patch exhibits substantial potential for clinical applications in the treatment of infected DW.<br /> (© 2024 Wiley‐VCH GmbH.)
- Subjects :
- Animals
Mice
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents administration & dosage
Needles
Silver chemistry
Silver pharmacology
Drug Delivery Systems methods
Male
Diabetes Mellitus, Experimental drug therapy
Silicon Dioxide chemistry
Reactive Oxygen Species metabolism
Humans
Wound Healing drug effects
Nanocomposites chemistry
Cerium chemistry
Cerium pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2192-2659
- Volume :
- 13
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Advanced healthcare materials
- Publication Type :
- Academic Journal
- Accession number :
- 38776526
- Full Text :
- https://doi.org/10.1002/adhm.202301985