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Daphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata.

Authors :
Tan L
Otsuki K
Kikuchi T
Zhou D
Li N
Huang L
Chen CH
Li W
Source :
Journal of natural medicines [J Nat Med] 2024 Sep; Vol. 78 (4), pp. 901-907. Date of Electronic Publication: 2024 May 23.
Publication Year :
2024

Abstract

Daphnane diterpenoids were recognized for their extensive range of potent biological activities. In the present study, phytochemical investigation including LC-MS/MS analysis resulted in the identification of five daphnane diterpenoid orthoesters (1-5). Among the five daphnane diterpenoids, two previously unreported compounds, daphnepedunins I and J (2 and 4) were isolated from Daphne pedunculata. The structure of new compounds was elucidated with extensive physicochemical and spectroscopic analyses. Their structure was characterized by the presence of an unusual odd-numbered aliphatic chain connected to an orthoester. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells, and the results indicated that compound 1 showed the most potent anti-HIV activity with an IC <subscript>50</subscript> value of 0.82 nM.<br /> (© 2024. The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy.)

Details

Language :
English
ISSN :
1861-0293
Volume :
78
Issue :
4
Database :
MEDLINE
Journal :
Journal of natural medicines
Publication Type :
Academic Journal
Accession number :
38780746
Full Text :
https://doi.org/10.1007/s11418-024-01826-x