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Metabolomics Analysis Identifies Differential Metabolites as Biomarkers for Acute Myocardial Infarction.
- Source :
-
Biomolecules [Biomolecules] 2024 Apr 29; Vol. 14 (5). Date of Electronic Publication: 2024 Apr 29. - Publication Year :
- 2024
-
Abstract
- Myocardial infarction (MI), including ST-segment elevation MI (STEMI) and non-ST-segment elevation MI (NSTEMI), is still a leading cause of death worldwide. Metabolomics technology was used to explore differential metabolites (DMs) as potential biomarkers for early diagnosis of STEMI and NSTEMI. In the study, 2531 metabolites, including 1925 DMs, were discovered. In the selected 27 DMs, 14 were successfully verified in a new cohort, and the AUC values were all above 0.8. There were 10 in STEMI group, namely L-aspartic acid, L-acetylcarnitine, acetylglycine, decanoylcarnitine, hydroxyphenyllactic acid, ferulic acid, itaconic acid, lauroylcarnitine, myristoylcarnitine, and cis-4-hydroxy-D-proline, and 5 in NSTEMI group, namely L-aspartic acid, arachidonic acid, palmitoleic acid, D-aspartic acid, and palmitelaidic acid. These 14 DMs may be developed as biomarkers for the early diagnosis of MI with high sensitivity and specificity. These findings have particularly important clinical significance for NSTEMI patients because these patients have no typical ECG changes.
- Subjects :
- Humans
Male
Middle Aged
Female
Aged
ST Elevation Myocardial Infarction diagnosis
ST Elevation Myocardial Infarction metabolism
Non-ST Elevated Myocardial Infarction diagnosis
Non-ST Elevated Myocardial Infarction metabolism
Metabolome
Biomarkers metabolism
Metabolomics methods
Myocardial Infarction diagnosis
Myocardial Infarction metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2218-273X
- Volume :
- 14
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biomolecules
- Publication Type :
- Academic Journal
- Accession number :
- 38785939
- Full Text :
- https://doi.org/10.3390/biom14050532