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Metabolomics Analysis Identifies Differential Metabolites as Biomarkers for Acute Myocardial Infarction.

Authors :
Zhou J
Hou HT
Song Y
Zhou XL
Chen HX
Zhang LL
Xue HM
Yang Q
He GW
Source :
Biomolecules [Biomolecules] 2024 Apr 29; Vol. 14 (5). Date of Electronic Publication: 2024 Apr 29.
Publication Year :
2024

Abstract

Myocardial infarction (MI), including ST-segment elevation MI (STEMI) and non-ST-segment elevation MI (NSTEMI), is still a leading cause of death worldwide. Metabolomics technology was used to explore differential metabolites (DMs) as potential biomarkers for early diagnosis of STEMI and NSTEMI. In the study, 2531 metabolites, including 1925 DMs, were discovered. In the selected 27 DMs, 14 were successfully verified in a new cohort, and the AUC values were all above 0.8. There were 10 in STEMI group, namely L-aspartic acid, L-acetylcarnitine, acetylglycine, decanoylcarnitine, hydroxyphenyllactic acid, ferulic acid, itaconic acid, lauroylcarnitine, myristoylcarnitine, and cis-4-hydroxy-D-proline, and 5 in NSTEMI group, namely L-aspartic acid, arachidonic acid, palmitoleic acid, D-aspartic acid, and palmitelaidic acid. These 14 DMs may be developed as biomarkers for the early diagnosis of MI with high sensitivity and specificity. These findings have particularly important clinical significance for NSTEMI patients because these patients have no typical ECG changes.

Details

Language :
English
ISSN :
2218-273X
Volume :
14
Issue :
5
Database :
MEDLINE
Journal :
Biomolecules
Publication Type :
Academic Journal
Accession number :
38785939
Full Text :
https://doi.org/10.3390/biom14050532