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Enantioselective de novo synthesis of 14-hydroxy-6-oxomorphinans.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Jun 06; Vol. 60 (47), pp. 6007-6010. Date of Electronic Publication: 2024 Jun 06. - Publication Year :
- 2024
-
Abstract
- The enantioselective de novo synthesis of pharmacologically important 14-hydroxy-6-oxomorphinans is described. 4,5-Desoxynaltrexone and 4,5-desoxynaloxone were prepared using this route and their biological activities against the opioid receptors were measured.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 60
- Issue :
- 47
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 38787679
- Full Text :
- https://doi.org/10.1039/d4cc01788a