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A study at the wildlife-livestock interface unveils the potential of feral swine as a reservoir for extended-spectrum β-lactamase-producing Escherichia coli.
A study at the wildlife-livestock interface unveils the potential of feral swine as a reservoir for extended-spectrum β-lactamase-producing Escherichia coli.
- Source :
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Journal of hazardous materials [J Hazard Mater] 2024 Jul 15; Vol. 473, pp. 134694. Date of Electronic Publication: 2024 May 22. - Publication Year :
- 2024
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Abstract
- Wildlife is known to serve as carriers and sources of antimicrobial resistance (AMR). Due to their unrestricted movements and behaviors, they can spread antimicrobial resistant bacteria among livestock, humans, and the environment, thereby accelerating the dissemination of AMR. Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae is one of major concerns threatening human and animal health, yet transmission mechanisms at the wildlife-livestock interface are not well understood. Here, we investigated the mechanisms of ESBL-producing bacteria spreading across various hosts, including cattle, feral swine, and coyotes in the same habitat range, as well as from environmental samples over a two-year period. We report a notable prevalence and clonal dissemination of ESBL-producing E. coli in feral swine and coyotes, suggesting their persistence and adaptation within wildlife hosts. In addition, in silico studies showed that horizontal gene transfer, mediated by conjugative plasmids and insertion sequences elements, may play a key role in spreading the ESBL genes among these bacteria. Furthermore, the shared gut resistome of cattle and feral swine suggests the dissemination of antibiotic resistance genes at the wildlife-livestock interface. Taken together, our results suggest that feral swine may serve as a reservoir of ESBL-producing E. coli.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Swine
Cattle
Gene Transfer, Horizontal
Livestock microbiology
Drug Resistance, Bacterial
Escherichia coli Infections microbiology
Escherichia coli Infections veterinary
Escherichia coli genetics
Escherichia coli drug effects
Escherichia coli enzymology
beta-Lactamases genetics
beta-Lactamases metabolism
Animals, Wild microbiology
Disease Reservoirs microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3336
- Volume :
- 473
- Database :
- MEDLINE
- Journal :
- Journal of hazardous materials
- Publication Type :
- Academic Journal
- Accession number :
- 38788585
- Full Text :
- https://doi.org/10.1016/j.jhazmat.2024.134694