Back to Search
Start Over
Tolerability of perampanel: A retrospective study at the department of psychiatry.
- Source :
-
Epilepsy & behavior : E&B [Epilepsy Behav] 2024 Jul; Vol. 156, pp. 109797. Date of Electronic Publication: 2024 May 23. - Publication Year :
- 2024
-
Abstract
- Purpose: We aimed to identify factors that contribute to the discontinuation of perampanel.<br />Methods: We retrospectively analyzed patients with epilepsy at the Department of Psychiatry, Hokkaido University Hospital. We evaluated the factors contributing to perampanel discontinuation as primary outcomes using Cox proportional hazards regression. Then, we explored the components contributing to the primary outcomes using logistic regression analysis.<br />Results: A total of 118 patients were included, 44.9% of whom discontinued participation, 22.0% had intellectual disability, and 23.7% had a psychiatric disorder other than intellectual disability. Adverse effects occurred in 65% of the patients, 23.7% had psychiatric adverse effects (PAE), and 49.2% had common adverse effects (CAE). The effect of PER to suppress seizures was confirmed in 65.3% of them. Discontinuation was influenced by non-response (Hazard Ratio (HR) 6.70, 95% Confidence Interval (CI) 3.42-13.1), the occurrence of PAE (HR 3.68, 95% CI 1.89-7.16), CAE (HR 1.90, 95% CI 1.06-3.41), and comorbid psychiatric disorders (HR 2.35, 95% CI 1.21-4.59). Moreover, comorbid intellectual disability correlated with a low risk of PAE (OR 0.19, 95% CI 0.04-0.89).<br />Conclusion: The discontinuation of perampanel is influenced by poor efficacy and the occurrence of common/psychiatric adverse effects. The discontinuation of perampanel is influenced by poor efficacy and the occurrence of common/psychiatric adverse effects. Consideration of factors contributing to perampanel discontinuation may assist in determining the indication for perampanel treatment.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Female
Male
Retrospective Studies
Middle Aged
Adult
Epilepsy drug therapy
Epilepsy epidemiology
Aged
Young Adult
Intellectual Disability epidemiology
Adolescent
Pyridones adverse effects
Pyridones therapeutic use
Nitriles adverse effects
Anticonvulsants adverse effects
Anticonvulsants therapeutic use
Mental Disorders epidemiology
Mental Disorders drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1525-5069
- Volume :
- 156
- Database :
- MEDLINE
- Journal :
- Epilepsy & behavior : E&B
- Publication Type :
- Academic Journal
- Accession number :
- 38788658
- Full Text :
- https://doi.org/10.1016/j.yebeh.2024.109797