Interleukin 21 promotes IgG1 + plasma cell differentiation instead of class switching to IgE via Blimp1 expression.

Authors :: Hashiguchi M
Asatsuma-Okumura T
Iwai Y
Source :: European journal of immunology [Eur J Immunol] 2024 Aug; Vol. 54 (8), pp. e2451041. Date of Electronic Publication: 2024 May 25.
Publication Year :: 2024
Abstract: IgE is induced by the presence of IL-4 by class switching from IgM through IgG1 to IgE. IL-21 inhibits the IgE class switch by induction of Blimp1 leading to Stat6 and AID downregulation, and plasmablast/plasma cell differentiation.<br /> (© 2024 The Author(s). European Journal of Immunology published by Wiley‐VCH GmbH.)

Subjects :: Animals
Mice
Interleukin-4 immunology
Interleukin-4 metabolism
Interleukin-21
Positive Regulatory Domain I-Binding Factor 1 genetics
Positive Regulatory Domain I-Binding Factor 1 metabolism
Plasma Cells immunology
Cell Differentiation immunology
Immunoglobulin E immunology
Immunoglobulin Class Switching
Immunoglobulin G immunology
Interleukins metabolism
Interleukins immunology

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