Sphincter of oddi dysfunction induced by ketamine: A case report.

Authors :: Sharma NR
Basnet A
Lamichhane S
Tiwari K
Varghese J
Gautam S
Pokhrel M
Source :: Clinical case reports [Clin Case Rep] 2024 May 24; Vol. 12 (6), pp. e9016. Date of Electronic Publication: 2024 May 24 (Print Publication: 2024).
Publication Year :: 2024
Abstract: Key Clinical Message: Chronic ketamine use can lead to sphincter of oddi dysfunction (SOD), causing various hepatobiliary complications. Recognizing substance abuse history is vital for early detection. Timely intervention can prevent irreversible liver and pancreas damage.<br />Abstract: Ketamine is commonly abused as a recreational drug worldwide due to its ability to induce euphoria-like effects. Ketamine abuse is associated with many hepatobiliary side effects ranging from cholestasis to biliary sepsis and death. Here we present a case of a young 29-year female with upper abdominal pain due to SOD resulting from chronic use of ketamine. SOD can result in obstruction or dysfunction of the bile and pancreatic ducts. Ketamine induces SOD by activation of the muscarinic receptors in the sphincter of oddi. Detail history of substance abuse is crucial for early identification of ketamine-induced SOD. Early identification and treatment of this rare condition can prevent permanent injury to the liver and pancreas.<br />Competing Interests: None.<br /> (© 2024 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd.)