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Unraveling CCL20's role by regulating Th17 cell chemotaxis in experimental autoimmune prostatitis.
- Source :
-
Journal of cellular and molecular medicine [J Cell Mol Med] 2024 May; Vol. 28 (10), pp. e18445. - Publication Year :
- 2024
-
Abstract
- Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), a prevalent urological ailment, exerts a profound influence upon the well-being of the males. Autoimmunity driven by Th17 cells has been postulated as a potential factor in CP/CPPS pathogenesis. Nonetheless, elucidating the precise mechanisms governing Th17 cell recruitment to the prostate, triggering inflammation, remained an urgent inquiry. This study illuminated that CCL20 played a pivotal role in attracting Th17 cells to the prostate, thereby contributing to prostatitis development. Furthermore, it identified prostate stromal cells and immune cells as likely sources of CCL20. Additionally, this research unveiled that IL-17A, released by Th17 cells, could stimulate macrophages to produce CCL20 through the NF-κB/MAPK/PI3K pathway. The interplay between IL-17A and CCL20 establishes a positive feedback loop, which might serve as a critical mechanism underpinning the development of chronic prostatitis, thus adding complexity to its treatment challenges.<br /> (© 2024 The Author(s). Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
- Subjects :
- Male
Animals
Mice
Macrophages metabolism
Macrophages immunology
Disease Models, Animal
NF-kappa B metabolism
Signal Transduction
Humans
Mice, Inbred C57BL
Prostate pathology
Prostate metabolism
Prostate immunology
Phosphatidylinositol 3-Kinases metabolism
Autoimmunity
Prostatitis immunology
Prostatitis pathology
Prostatitis metabolism
Th17 Cells immunology
Th17 Cells metabolism
Chemokine CCL20 metabolism
Chemokine CCL20 genetics
Interleukin-17 metabolism
Interleukin-17 immunology
Autoimmune Diseases immunology
Autoimmune Diseases metabolism
Autoimmune Diseases pathology
Chemotaxis
Subjects
Details
- Language :
- English
- ISSN :
- 1582-4934
- Volume :
- 28
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of cellular and molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38801403
- Full Text :
- https://doi.org/10.1111/jcmm.18445