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Genipin crosslinked quaternary ammonium chitosan hydrogels for wound dressings.

Authors :
Wang L
Ding X
Li J
Li M
Ding P
Guo W
Wu Q
Sun Y
Jiang G
Okoro OV
Mirzaei M
Shavandi A
Fan L
Nie L
Source :
Biomedical materials (Bristol, England) [Biomed Mater] 2024 Jun 26; Vol. 19 (4). Date of Electronic Publication: 2024 Jun 26.
Publication Year :
2024

Abstract

Bacterial infection can lead to various complications, such as inflammations on surrounding tissues, which can prolong wound healing and thus represent a significant clinical and public healthcare problem. Herein, a report on the fabrication of a novel genipin/quaternized chitosan (CS) hydrogel for wound dressing is presented. The hydrogel was prepared by mixing quaternized CS and genipin under 35 °C bath. The hydrogels showed porous structure (250-500 μm) and mechanical properties (3000-6000 Pa). In addition, the hydrogels displayed self-healing ability and adhesion performance on different substrates. Genipin crosslinked quaternized CS hydrogels showed antibacterial activities against E. coli and S. aureus . The CCK-8 and fluorescent images confirmed the cytocompatibility of hydrogels by seeding with NIH-3T3 cells. The present study showed that the prepared hydrogel has the potential to be used as wound dressing.<br /> (© 2024 IOP Publishing Ltd.)

Details

Language :
English
ISSN :
1748-605X
Volume :
19
Issue :
4
Database :
MEDLINE
Journal :
Biomedical materials (Bristol, England)
Publication Type :
Academic Journal
Accession number :
38815598
Full Text :
https://doi.org/10.1088/1748-605X/ad525f