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Transgenic female mice producing trans 10, cis 12-conjugated linoleic acid present excessive prostaglandin E2, adrenaline, corticosterone, glucagon, and FGF21.
- Source :
-
Scientific reports [Sci Rep] 2024 May 30; Vol. 14 (1), pp. 12430. Date of Electronic Publication: 2024 May 30. - Publication Year :
- 2024
-
Abstract
- Dietary trans 10, cis 12-conjugated linoleic acid (t10c12-CLA) is a potential candidate in anti-obesity trials. A transgenic mouse was previously successfully established to determine the anti-obesity properties of t10c12-CLA in male mice that could produce endogenous t10c12-CLA. To test whether there is a different impact of t10c12-CLA on lipid metabolism in both sexes, this study investigated the adiposity and metabolic profiles of female Pai mice that exhibited a dose-dependent expression of foreign Pai gene and a shift of t10c12-CLA content in tested tissues. Compared to their gender-match wild-type littermates, Pai mice had no fat reduction but exhibited enhanced lipolysis and thermogenesis by phosphorylated hormone-sensitive lipase and up-regulating uncoupling proteins in brown adipose tissue. Simultaneously, Pai mice showed hepatic steatosis and hypertriglyceridemia by decreasing gene expression involved in lipid and glucose metabolism. Further investigations revealed that t10c10-CLA induced excessive prostaglandin E2, adrenaline, corticosterone, glucagon and inflammatory factors in a dose-dependent manner, resulting in less heat release and oxygen consumption in Pai mice. Moreover, fibroblast growth factor 21 overproduction only in monoallelic Pai/wt mice indicates that it was sensitive to low doses of t10c12-CLA. These results suggest that chronic t10c12-CLA has system-wide effects on female health via synergistic actions of various hormones.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Female
Mice
Thermogenesis drug effects
Thermogenesis genetics
Male
Lipid Metabolism drug effects
Adipose Tissue, Brown metabolism
Adipose Tissue, Brown drug effects
Fatty Liver metabolism
Fatty Liver genetics
Lipolysis drug effects
Hypertriglyceridemia metabolism
Hypertriglyceridemia genetics
Adiposity drug effects
Fibroblast Growth Factors metabolism
Fibroblast Growth Factors genetics
Mice, Transgenic
Linoleic Acids, Conjugated pharmacology
Linoleic Acids, Conjugated metabolism
Corticosterone metabolism
Dinoprostone metabolism
Glucagon metabolism
Epinephrine metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 38816541
- Full Text :
- https://doi.org/10.1038/s41598-024-63282-7