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Guidelines for in vivo models of developmental programming of cardiovascular disease risk.
- Source :
-
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2024 Jul 01; Vol. 327 (1), pp. H221-H241. Date of Electronic Publication: 2024 May 31. - Publication Year :
- 2024
-
Abstract
- Research using animals depends on the generation of offspring for use in experiments or for the maintenance of animal colonies. Although not considered by all, several different factors preceding and during pregnancy, as well as during lactation, can program various characteristics in the offspring. Here, we present the most common models of developmental programming of cardiovascular outcomes, important considerations for study design, and provide guidelines for producing and reporting rigorous and reproducible cardiovascular studies in offspring exposed to normal conditions or developmental insult. These guidelines provide considerations for the selection of the appropriate animal model and factors that should be reported to increase rigor and reproducibility while ensuring transparent reporting of methods and results.
Details
- Language :
- English
- ISSN :
- 1522-1539
- Volume :
- 327
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Heart and circulatory physiology
- Publication Type :
- Academic Journal
- Accession number :
- 38819382
- Full Text :
- https://doi.org/10.1152/ajpheart.00060.2024