Exploring the solubility and intermolecular interactions of biologically significant amino acids l-serine and L-cysteine in binary mixtures of H 2 O + DMF, H 2 O + DMSO and H 2 O + ACN in temperature range from T = 288.15 K to 308.15 K.

In the presented work, a study on the solubility and intermolecular interactions of l-serine and L-cysteine was carried out in binary mixtures of H ₂ O + dimethylformamide (DMF), H ₂ O + dimethylsulfoxide (DMSO), and H ₂ O + acetonitrile (ACN) in the temperature range of T = 288.15 K to 308.15 K. l-serine exhibited the highest solubility in water, while L-cysteine was more soluble in water-DMF. The solvation process was assessed through standard Gibbs energy calculations, indicating the solvation stability order: water-ACN > water-DMSO > water-DMF for l-serine, and water-DMF > water-DMSO > water-ACN for L-cysteine. This study also explored the influence of these amino acids on solvent-solvent interactions, revealing changes in chemical entropies and self-association patterns within the binary solvent mixtures.
Competing Interests: Declaration of competing interest The authors did not disclose any potential conflict of interest.
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