Back to Search
Start Over
Effects of povidone-iodine wound irrigation on surgical site infection in gastroenterological surgery: A randomized controlled trial.
- Source :
-
Surgery [Surgery] 2024 Aug; Vol. 176 (2), pp. 371-378. Date of Electronic Publication: 2024 Jun 01. - Publication Year :
- 2024
-
Abstract
- Background: The irrigation efficacy of a povidone-iodine solution to prevent surgical site infection is still controversial. We assessed the irrigation effect with a povidone-iodine solution on the incidence of surgical site infection after gastroenterological surgery.<br />Methods: This study is a single-center, prospective, randomized, blinded-end point superiority trial for surgical wound irrigation. Patients undergoing gastroenterological surgery were randomly assigned in a 1:1 replacement ratio using computer-generated randomization. Patients were grouped according to their surgical wound treatment into the control group using the normal sterile saline and the povidone-iodine group using 10% povidone-iodine solution after the NS solution. The main finding was 30-day surgical site infections assessed in the full analysis set.<br />Results: From November 2020 to December 2022, 697 of 894 patients were eligible for the study, among which 347 were in the povidone-iodine group and 350 in the control group. Thirty-day surgical site infections occurred in 100 (14%) patients-54 (16%) in the povidone-iodine group and 46 (13%) in the control group (odds ratio, 1.229; 95% CI, 0.800-1.889; P = .406). Superficial incisional surgical site infections occurred in 30 (9%) and 15 (4%) patients, respectively (odds ratio, 2.154; 95% CI, 1.134-4.090; P = .026). Only 3 patients (1%) in the control group developed adverse skin reactions.<br />Conclusion: This study examined the irrigation efficacy of povidone-iodine for surgical site infection prevention compared to control in gastroenterological surgery. Povidone-iodine wound irrigation has shown no additional beneficial effect on the occurrence of surgical site infections.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Male
Female
Middle Aged
Prospective Studies
Aged
Adult
Incidence
Treatment Outcome
Povidone-Iodine administration & dosage
Povidone-Iodine therapeutic use
Surgical Wound Infection prevention & control
Surgical Wound Infection epidemiology
Surgical Wound Infection etiology
Therapeutic Irrigation methods
Anti-Infective Agents, Local administration & dosage
Digestive System Surgical Procedures adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1532-7361
- Volume :
- 176
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 38825398
- Full Text :
- https://doi.org/10.1016/j.surg.2024.04.034