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Salivary duct carcinoma with squamous differentiation: histomorphological and immunophenotypical analysis of six cases.
- Source :
-
Histopathology [Histopathology] 2024 Oct; Vol. 85 (4), pp. 590-597. Date of Electronic Publication: 2024 Jun 03. - Publication Year :
- 2024
-
Abstract
- Background and Aims: Salivary duct carcinoma (SDC) is an aggressive salivary malignancy with multiple morphological subtypes. Primary salivary squamous cell carcinoma (SCC) requires exclusion of high-grade salivary malignancies and metastatic disease and is considered exceptionally rare. We report six cases of SDC with resemblance to SCC on account of variable, but often extensive, squamous differentiation.<br />Methods and Results: A retrospective review (2009-2023) at two institutions of SDC with histological and immunophenotypical evidence of squamous differentiation identified six cases. Medical charts and available glass slides were reviewed. There were five males and one female with a median age of 63 years, with tumours involving the parotid (five of six) and submandibular (one of six) glands. All six tumours showed a conventional SDC component comprising < 5-90% of viable tumour. Squamous differentiation comprised 10-95%+ (> 75% in three of six cases) of total viable tumour, and demonstrated CK5/6, p63 and/or p40 immunoexpression in all cases. A sarcomatoid component, comprising 10-60% of viable tumour, was present in three of six (50%) cases. All tumours were androgen receptor (AR)-positive, but only two of six (33.3%) retained AR immunoreactivity in the squamous component. Metastatic SDC to regional lymph nodes exhibited exclusive squamous differentiation in two of six (33.3%) cases.<br />Conclusion: Squamous differentiation, histologically and immunophenotypically, can be extensive in SDC. AR expression may be lost in the squamous component and metastases may demonstrate only squamous differentiation. These findings cast further doubt on the existence of primary salivary SCC. SDC should be considered whenever encountering a carcinoma with squamous differentiation in major salivary glands or within cervical lymph nodes in the setting of a salivary mass.<br /> (© 2024 The Author(s). Histopathology published by John Wiley & Sons Ltd.)
- Subjects :
- Humans
Male
Female
Middle Aged
Aged
Retrospective Studies
Carcinoma, Ductal pathology
Carcinoma, Ductal diagnosis
Salivary Ducts pathology
Squamous Cell Carcinoma of Head and Neck pathology
Salivary Gland Neoplasms pathology
Carcinoma, Squamous Cell pathology
Immunophenotyping
Biomarkers, Tumor analysis
Biomarkers, Tumor metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2559
- Volume :
- 85
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Histopathology
- Publication Type :
- Academic Journal
- Accession number :
- 38828680
- Full Text :
- https://doi.org/10.1111/his.15217