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High variance in quantification of Mycobacterium tuberculosis at low bacterial loads and with differentially detectable mycobacteria.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Jul 09; Vol. 68 (7), pp. e0160123. Date of Electronic Publication: 2024 Jun 03. - Publication Year :
- 2024
-
Abstract
- We examined the correlation between three different methods of Mycobacterium tuberculosis quantification: time to positivity (TTP), log <subscript>10</subscript> CFU, and an assay to detect differentially detectable M. tuberculosis (DD Mtb) from three different prospective studies. Participants with DD Mtb have significantly more variation in the CFU/TTP correlation than participants with no DD Mtb ( P < 0.001). This may impact the design of early bactericidal activity studies that use TTP as the primary outcome.<br />Competing Interests: The authors declare no conflict of interest.
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 68
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 38829050
- Full Text :
- https://doi.org/10.1128/aac.01601-23