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Ondansetron or beta-sitosterol antagonizes inflammatory responses in liver, kidney, lung and heart tissues of irradiated arthritic rats model.
- Source :
-
International journal of immunopathology and pharmacology [Int J Immunopathol Pharmacol] 2024 Jan-Dec; Vol. 38, pp. 3946320241260635. - Publication Year :
- 2024
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Abstract
- Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder mainly affecting joints, yet the systemic inflammation can influence other organs and tissues. The objective of this study was to unravel the ameliorative capability of Ondansetron (O) or β-sitosterol (BS) against inflammatory reactions and oxidative stress that complicates Extra-articular manifestations (EAM) in liver, kidney, lung, and heart of arthritic and arthritic irradiated rats.<br />Methods: This was accomplished by exposing adjuvant-induced arthritis (AIA) rats to successive weekly fractions of total body γ-irradiation (2 Gray (Gy)/fraction once per week for four weeks, up to a total dose of 8 Gy). Arthritic and/or arthritic irradiated rats were either treated with BS (40 mg/kg b.wt. /day, orally) or O (2 mg/kg) was given ip) or were kept untreated as model groups.<br />Results: Body weight changes, paw circumference, oxidative stress indices, inflammatory response biomarkers, expression of Janus kinase-2 (JAK-2), Signal transducer and activator of transcription 3 (STAT3), high mobility group box1 (HMGB1), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), as well as pro- and anti-inflammatory mediators in the target organs, besides histopathological examination of ankle joints and extra-articular tissues. Treatment of arthritic and/or arthritic irradiated rats with BS or O powerfully alleviated changes in body weight gain, paw swelling, oxidative stress, inflammatory reactions, and histopathological degenerative alterations in articular and non-articular tissues.<br />Conclusion: The obtained data imply that BS or O improved the articular and EAM by regulating oxidative and inflammatory indices in arthritic and arthritic irradiated rats.<br />Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Subjects :
- Animals
Rats
Male
HMGB1 Protein metabolism
Heart drug effects
Heart radiation effects
Myocardium pathology
Myocardium metabolism
Inflammation pathology
Inflammation metabolism
Anti-Inflammatory Agents pharmacology
STAT3 Transcription Factor metabolism
Rats, Wistar
Sitosterols pharmacology
Lung drug effects
Lung pathology
Lung metabolism
Lung radiation effects
Arthritis, Experimental pathology
Arthritis, Experimental drug therapy
Arthritis, Experimental metabolism
Kidney drug effects
Kidney pathology
Kidney metabolism
Kidney radiation effects
Oxidative Stress drug effects
Liver drug effects
Liver pathology
Liver metabolism
Liver radiation effects
Ondansetron pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2058-7384
- Volume :
- 38
- Database :
- MEDLINE
- Journal :
- International journal of immunopathology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 38831558
- Full Text :
- https://doi.org/10.1177/03946320241260635