Modular Assembly of Pyrrolo[3,4- c ]isoquinolines through Rh-Catalyzed Cascade C-H Activation/Annulation of O -Methyl Aryloximes with Maleimides.

An efficient and practical strategy for the construction of pyrrolo[3,4- c ]isoquinolines via Rh(III)-catalyzed cascade C-H activation and subsequential annulation process from easily available O -methyl aryloximes and maleimides has been disclosed. This facile protocol does not require any inert atmosphere protection with good efficiency in a low loading of catalyst and exhibits good functional group tolerance and broad substrate scope. Notably, the as-prepared products show potential photophysical properties.