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Enhancing the Biological Performance of Titanium Alloy through In Situ Modulation of the Surface Nanostructure: Near-Infrared-Responsive Antibacterial Function and Osteoinductivity.
- Source :
-
ACS applied bio materials [ACS Appl Bio Mater] 2024 Jun 17; Vol. 7 (6), pp. 3900-3914. Date of Electronic Publication: 2024 Jun 05. - Publication Year :
- 2024
-
Abstract
- The poor clinical performance of titanium and its alloy implants is mainly attributed to their lack of antibacterial ability and poor osseointegration. The key and challenge lie in how to enhance their osteoinductivity while imparting antibacterial capability. In this study, a titanium oxide metasurface with light-responsive behavior was constructed on the surface of titanium alloy using an alkaline-acid bidirectional hydrothermal method. The effects of the acid type, acid concentration, hydrothermal time, hydrothermal temperature, and subsequent heat treatments on the optical behavior of the metasurface were systematically investigated with a focus on exploring the influence of the metasurface and photodynamic reaction on the osteogenic activity of osteoblasts. Results show that the type of acid and heat treatment significantly affect the light absorption of the titanium alloy surface, with HCl and post-heat-treatment favoring redshift in the light absorption. Under 808 nm near-infrared (NIR) irradiation for 10 min, in vitro antibacterial experiments demonstrate that the antibacterial rate of the metasurface titanium alloy against Staphylococcus aureus and Escherichia coli were 96.87% and 99.27%, respectively. In vitro cell experiments demonstrate that the nanostructure facilitates cell adhesion, proliferation, differentiation, and expression of osteogenic-related genes. Surprisingly, the nanostructure promoted the expression of relevant osteogenic genes of MC3T3-E1 under 808 nm NIR irradiation. This study provides a method for the surface modification of titanium alloy implants.
- Subjects :
- Microbial Sensitivity Tests
Particle Size
Animals
Mice
Osteogenesis drug effects
Osteoblasts drug effects
Osteoblasts cytology
Cell Proliferation drug effects
Osseointegration drug effects
Titanium chemistry
Titanium pharmacology
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents chemical synthesis
Staphylococcus aureus drug effects
Alloys chemistry
Alloys pharmacology
Escherichia coli drug effects
Nanostructures chemistry
Surface Properties
Materials Testing
Infrared Rays
Biocompatible Materials chemistry
Biocompatible Materials pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2576-6422
- Volume :
- 7
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- ACS applied bio materials
- Publication Type :
- Academic Journal
- Accession number :
- 38840339
- Full Text :
- https://doi.org/10.1021/acsabm.4c00244