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The impact of sickle cell disease and its treatment on ovarian reserve in reproductive-aged Black women.
- Source :
-
British journal of haematology [Br J Haematol] 2024 Aug; Vol. 205 (2), pp. 674-685. Date of Electronic Publication: 2024 Jun 06. - Publication Year :
- 2024
-
Abstract
- We compared serum anti-Mullerian hormone (AMH) levels in women with sickle cell disease (SCD) (n = 152) to those of Black comparison women (n = 128) between the ages of 20 and 45 years and evaluated the impact of hydroxyurea (HU) and iron overload on ovarian reserve in those with SCD. SCD treatment was abstracted from medical records. Linear regression models were fit to examine the relationship between log(AMH) and SCD, adjusting for age. The analysis was repeated to account for HU use (current, previous, never) and iron overload (ferritin ≥1000 ng/mL vs. <1000 ng/mL). AMH estimates among women with SCD were lower than those among comparison women (2.23, 95% confidence interval [CI] 1.80-2.76 vs. 4.12, 95% CI 3.11-5.45, respectively). Women with SCD who were currently using HU had 63% lower (95% CI 43-76) AMH values than comparison women; those with SCD with prior or no HU use also had lower AMH estimates than comparison women, but the difference was less pronounced. There were no differences in predicted AMH values among women with SCD for those with and without iron overload. Women with SCD and low AMH may have a shorter reproductive window and may benefit from referral to a reproductive specialist.<br /> (© 2024 British Society for Haematology and John Wiley & Sons Ltd.)
- Subjects :
- Humans
Female
Adult
Middle Aged
Iron Overload etiology
Iron Overload drug therapy
Iron Overload blood
Young Adult
Black or African American
Anemia, Sickle Cell drug therapy
Anemia, Sickle Cell blood
Anemia, Sickle Cell complications
Ovarian Reserve
Anti-Mullerian Hormone blood
Hydroxyurea therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 205
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 38841818
- Full Text :
- https://doi.org/10.1111/bjh.19582