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Withanolide Profile and Acetylcholinesterase Inhibitory Activity of Two Argentinean Jaborosa Species.
- Source :
-
Planta medica [Planta Med] 2024 Jun; Vol. 90 (7-08), pp. 561-575. Date of Electronic Publication: 2024 Jun 06. - Publication Year :
- 2024
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Abstract
- Acetylcholinesterase (AChE) inhibitors are still an important option for managing symptoms of mild to moderate Alzheimer's disease. In this study, we aimed to evaluate the potential in vitro AChE inhibitory activity of two Argentinian endemic Solanaceae species, Jaborosa bergii and J. runcinata . UHPLC-DAD-HRMS metabolite profiling revealed the presence of withanolides in the active CH <subscript>2</subscript> Cl <subscript>2</subscript> subextracts. Their fractionation led to the isolation and identification of two known spiranoid withanolides from J. runcinata and three new withanolides with a skeleton similar to that of trechonolide-type withanolides from J. bergii . The known compounds showed moderate AChE inhibitory activity, while the new ones were inactive.<br />Competing Interests: The authors declare that they have no conflict of interest.<br /> (Thieme. All rights reserved.)
- Subjects :
- Argentina
Acetylcholinesterase metabolism
Acetylcholinesterase drug effects
Molecular Structure
Plant Extracts pharmacology
Plant Extracts chemistry
Withanolides pharmacology
Withanolides chemistry
Withanolides isolation & purification
Cholinesterase Inhibitors pharmacology
Cholinesterase Inhibitors chemistry
Solanaceae chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0221
- Volume :
- 90
- Issue :
- 7-08
- Database :
- MEDLINE
- Journal :
- Planta medica
- Publication Type :
- Academic Journal
- Accession number :
- 38843796
- Full Text :
- https://doi.org/10.1055/a-2255-7096