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Response to COVID-19 vaccination imaged by PD-L1 PET scanning.
- Source :
-
EJNMMI reports [EJNMMI Rep] 2024 Jun 07; Vol. 8 (1), pp. 16. Date of Electronic Publication: 2024 Jun 07. - Publication Year :
- 2024
-
Abstract
- Background: During a phase 0 clinical trial of an investigational programmed cell death ligand-1 (PD-L1) PET tracer in patients with non-small cell lung cancer (NSCLC), three patients received booster doses of COVID-19 vaccines before PD-L1 imaging.<br />Methods: Five patients underwent whole-body PET/CT imaging with a novel PD-L1 tracer, constructed by attaching <superscript>89</superscript> Zr to the anti PD-L1 antibody durvalumab. Intramuscular (deltoid) booster doses of mRNA BNT162b2 COVID-19 mRNA vaccine were coincidentally given to three patients in the month before PD-L1 tracer injection.<br />Results: Two recently-vaccinated patients, in remission of NSCLC and receiving non-immunosuppressive cancer therapies (immunotherapy and tyrosine kinase inhibitor respectively), showed increasing PD-L1 tracer uptake in ipsilateral axillary lymph nodes. No asymmetric nodal uptake was seen in a third recently-vaccinated patient who was receiving immunosuppressive chemotherapy, or in two patients not recently-vaccinated.<br />Conclusion: Immune response to mRNA BNT162b2 vaccination may involve regulation by PD-L1 positive immune cells in local draining lymph nodes in immunocompetent patients.<br />Trial Registration: This trial was registered with the Australian New Zealand Clinical Trials Registry. Registration number ACTRN12621000171819. Date of Trial Registration 8/2/2021. Date of enrolment of 1st patient 11/4/2021. URL of trial registry record: https://www.australianclinicaltrials.gov.au/anzctr/trial/ACTRN12621000171819 .<br /> (© 2024. The Author(s).)
Details
- Language :
- English
- ISSN :
- 3005-074X
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- EJNMMI reports
- Publication Type :
- Academic Journal
- Accession number :
- 38844699
- Full Text :
- https://doi.org/10.1186/s41824-024-00196-7