Back to Search
Start Over
Genome-wide identification and characterization of large yellow croaker (Larimichthys crocea) suppressors of cytokine signaling (SOCS) in immune response to Pseudomonas plecoglossicida infection and acute hypoxia stress.
Genome-wide identification and characterization of large yellow croaker (Larimichthys crocea) suppressors of cytokine signaling (SOCS) in immune response to Pseudomonas plecoglossicida infection and acute hypoxia stress.
- Source :
-
Fish & shellfish immunology [Fish Shellfish Immunol] 2024 Aug; Vol. 151, pp. 109669. Date of Electronic Publication: 2024 Jun 06. - Publication Year :
- 2024
-
Abstract
- The suppressor of cytokine signaling (SOCS) gene family is a group of genes involved in the negative regulation of cytokine signal transduction. The members of this family play a crucial role in regulating immune and inflammatory processes. However, comprehensive investigations of these genes have not yet been conducted in the economically significant fish large yellow croaker (Larimichthys crocea). In this study, a total of 13 SOCS genes (LcSOCS1a, LcSOCS1b, LcSOCS2, LcSOCS3a, LcSOCS3b, LcSOCS4, LcSOCS5a, LcSOCS5b, LcSOCS6, LcSOCS7a, LcSOCS7b, LcCISHa and LcCISHb) were identified and analyzed in L. crocea. The phylogenetic tree revealed a high conservation of SOCS genes in evolution, and the gene structure and motif analysis indicated a high similarity in the structure of LcSOCSs in the same subfamily. In addition, the expression patterns of LcSOCSs showed that LcSOCS1b was significantly down-regulated in all time under acute hypoxia stress, but it was markedly up-regulated throughout the entire process after P. plecoglossicida infection, revealing its different immune effects to two stresses. Besides, LcSOCS2a, LcSOCS6 and LcSOCS7a only participated in acute hypoxic stress, while LcSOCS5a was more sensitive to P. plecoglossicida infection. In summary, these results indicated that SOCS genes were involved in stress responses to both biological and non-biological stimuli, setting the foundation for deeper study on the functions of SOCS genes.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Gene Expression Profiling veterinary
Stress, Physiological immunology
Stress, Physiological genetics
Sequence Alignment veterinary
Hypoxia genetics
Hypoxia immunology
Hypoxia veterinary
Perciformes immunology
Perciformes genetics
Fish Diseases immunology
Fish Proteins genetics
Fish Proteins immunology
Fish Proteins chemistry
Suppressor of Cytokine Signaling Proteins genetics
Suppressor of Cytokine Signaling Proteins immunology
Suppressor of Cytokine Signaling Proteins chemistry
Phylogeny
Immunity, Innate genetics
Pseudomonas Infections immunology
Pseudomonas Infections veterinary
Pseudomonas Infections genetics
Pseudomonas physiology
Gene Expression Regulation immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9947
- Volume :
- 151
- Database :
- MEDLINE
- Journal :
- Fish & shellfish immunology
- Publication Type :
- Academic Journal
- Accession number :
- 38849106
- Full Text :
- https://doi.org/10.1016/j.fsi.2024.109669